NLM 0000070324 00000 n Little Bright Eye) was achieved by HPLC-DAD-ESI-MS/MS. Carborundum abrasion technique was used to extract leaf epidermis–enriched mRNA, thus sampling the epidermome, or complement, of proteins expressed in the leaf epidermis. Catharanthus roseus (L.) G. Don a is known as the Madagascan periwinkle or the tropical periwinkle. Pharmacognosy of Catharanthus roseus (L.) G. Don (Sadabahar) Root and its Adulterants. Catharanthus roseus (L.) G. Don, also known as Madagascar periwinkle or Sadabahar, is a herbaceous plant belonging to the family Apocynaceae. The use of Catharanthus roseus by 30 Bapedi traditional healers to treat gonorrhoea in the Limpopo Province of South Africa, was investigated via a semi-structured questionnaire, supplemented with field observations. Biotechnological interventions on the genus Rauvolfia: recent trends and imminent prospects. Four distinct transformed cell lines were obtained with A. tumefaciens strains A281, BO542, and A. rhizogenes strain K599, and selected on hormone-free medium. 2016 Oct;54(10):2033-43. doi: 10.3109/13880209.2016.1140213. 0000078451 00000 n Catharanthus roseus (L.) G. Don, also known as Madagascar periwinkle or Sadabahar, is a herbaceous plant belonging to the family Apocynaceae. edu (M. M.) Funding information Medical Research Foundation of Oregon; Research Startup Funds Abstract The medicinal plant Catharanthus roseus produces numerous secondary metabolites 0000077583 00000 n 0000139741 00000 n The botanical nomenclature C. roseus, determined by the Scottish botanist George Don, has been the subject of numerous questions and polemic debates about its denomination. Catharanthus roseus (C. roseus) is an important medicinal plant distributed in many countries. 0000139080 00000 n 0000003953 00000 n Screening and kinetic studies of catharanthine and ajmalicine accumulation and their correlation with growth biomass in Catharanthus roseus hairy roots. The purpose of this work was to perform in silico analysis and to predict the three-dimensional structure of this protein that is not available. A plastid‐localized bona fide geranylgeranyl diphosphate synthase plays a necessary role in monoterpene indole alkaloid biosynthesis in Catharanthus roseus Sarma Rajeev Kumar Molecular Plant Biology and Biotechnology Lab, CSIR‐Central Institute of Medicinal and Aromatic Plants, Research … 0000072215 00000 n There are four important MIAs, vinblastine and vincristine used in the clinic as anti-cancer agents (Aslam et al., 2010), catharanthine which can reduce blood sugar content (Pan et al., 2012), and vindoline. 0000075567 00000 n Being a reservoir for more than 200 alkaloids, it reserves a place for itself in the list of important medicinal plants. Endangered in the wild, it is a fast-growing plant that is easy to cultivate. 11, 10 DECEMBER 2016 1811 *For correspondence. Mukherjee E, Gantait S, Kundu S, Sarkar S, Bhattacharyya S. Appl Microbiol Biotechnol. Four distinct transformed cell lines were obtained with A. tumefaciens strains A281, BO542, and A. rhizogenes strain K599, and selected on hormone-free medium. Biotechnol Bioeng. Catharanthus roseus (periwinkle) produces a wide range of terpenoid indole alkaloids, including several pharmaceutically important compounds, from the intermediate strictosidine. Abstract. Catharanthus roseus is a plant that has been utilised since ancient times to treat and manage various ailments such as DM . 0000080220 00000 n Physicochemical characterization was performed by Expasy’s Protparam server. 0000080634 00000 n Ultraviolet (UV)-B radiation acts as an elicitor to enhance the production of secondary metabolites in medicinal plants. 0000072537 00000 n 0000071977 00000 n 0000142557 00000 n 0000080009 00000 n The medicinal plant, Catharanthus roseus (C. roseus), accumulates a wide range of terpenoid indole alkaloids (TIAs). 0000135441 00000 n %%EOF Catharanthus roseus (C. roseus) is an important medicinal plant distributed in many countries. 0000069929 00000 n Pharmacognosy of Catharanthus roseus (L.) G. Don (Sadabahar) Root and its Adulterants. Rats were divided into six groups. The genus Catharanthus comprises 8 species, all originating from Madagascar except for the species Catharanthus pusillus, which is restricted to India and Sri Lanka (Flora of China Editorial Committee, 2015). 3.1.1 Creation of the genus Catharanthus. 0000082459 00000 n Periwinkle [Catharanthus roseus (L) G. Don] has become one of the very extensively investigated medicinal plants after the discovery of two powerful anti-cancer alkaloids, vinblastine and vincristine, in its leaves more than 50 years ago.These alkaloidal drugs are still in clinical use. Research Article Catharanthus roseus Combined with Ursolic Acid Attenuates Streptozotocin-Induced Diabetes through Insulin Secretion and Glycogen Storage Huda Mohammed Alkreathy 1 and Aftab Ahmad 2 1Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia Epub 2016 Mar 17. Research article; Open Access; Published: 21 October 2015 Anti-diabetic potential of Catharanthus roseus Linn. The content of ajmalicine reached 2.578 and 0.895 mg/g DW in callus and in cell suspension culture, respectively. However, the extraction of bioactive compound also results in the generation of large quantities of pollution with wasted solvents. 2020 Oct 12;13(10):303. doi: 10.3390/ph13100303. 0000141673 00000 n 0000089069 00000 n Anticancerous; Genetic transformation; Nanotechnology; Polyploidy; Secondary metabolite; Somatic embryogenesis. 0000070245 00000 n Nanotechnology is growing gradually in various fields of science like medical, agricultural and physical sciences. 0000093706 00000 n World Journal of Pharmaceutical Research and Catharanthus roseus) Bougainvillea . In this study, strictosidine synthase (STR) from Catharanthus roseus that plays an important role in alkaloid biosynthesis was selected. 0000140778 00000 n 0000070796 00000 n | Seeds of Catharanthus roseus ‘Pacifica Polka Dot’ were purchased from PanAmerican Seed and 900 seeds were sown at Taoyuan District Agricultural Research and Extension Station (TDARES). 0000134812 00000 n 0000141471 00000 n 0000143872 00000 n The complete mRNA sequence for the enzyme strictosidine synthase (SSS) was determined. Isolation, purification and maintenance of the endophytic fungus producing vinblastine and vincristine. Catharanthus roseus (L.) is a plant species known for its production of many pharmaceutically terpenoid indole alkaloids (TIAs). 0000073677 00000 n The Madagascar periwinkle (Catharanthus roseus in the family Apocynaceae) is an important medicinal plant and is the source of several widely marketed chemotherapeutic drugs. Catharanthus roseus L (apocyanaceae) also known as Vinca Rosea, is native to the Caribbean Basin and has historically been used to treat a wide assortment of diseases. Madagascar periwinkle (Catharanthus roseus) has become a model plant for secondary metabolism studies [].The medicinal plant C. roseus possesses a large number of terpenoid indole alkaloids (TIAs) among which over 130 compounds have been isolated and identified [].The production of the most valuable dimeric alkaloids vinblastine and vincristine are extremely low in wild-type C. roseus … 0000082703 00000 n KEY POINTS: • C. roseus yields anticancerous vincristine and vinblastine used in pharma industry. The aim of this study was to extract and identify the major constituents, namely, the indole alkaloids, from two Apocynaceae medicinal plant family species, Catharanthus roseus and Vinca minor when using different solvents (the alcohol mixtures, the imidazolium-based ionic liquids (IL) and the novel choline- and menthol-based deep eutectic solvents (DESs)) in ultrasound-assisted processes. Catharanthus roseus L. (G. Don) leaf disks were transformed by cocultivation with seven strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes. Cells were grown for 21 days, and alkaloid accumulation was monitored during this period. 1, pp. Abstract. A double-flowered mutant was identified from the ‘Pacifica Polka Dot’ population. Ethylene (ET) and methyl-jasmonate (MeJA) were previously reported as effective elicitors for the production of various valuable secondary metabolites of C. roseus, while a few ET or MeJA induced transcriptomic research is yet reported on this species. Jiayi Sun 1 International Journal of Crude Drug Research: Vol. 0000071425 00000 n The leaf juice or water decoction of Catharanthus roseus L. (Apocyanaceae) is used as a folk medicine for the treatment of diabetes all over the world. Gr… Keywords: The intricate networks of TIAs biosynthesis is regulated by all kinds of molecules such as plant signaling molecules (jasmonate acid, ethylene and nitric oxide), plant growth regulators, prenylated proteins and transcription factors. It is also commonly grown for its ornamental values and, due to ease of infection and distinctiveness of symptoms, is often used as the host for studies on phytoplasmas, an important group of uncultivated … 0000141901 00000 n The genus Catharanthus is closely related to the genus Vinca and the species C. roseus was formerly known as Vinca rosea. 0000139800 00000 n A plastid‐localized bona fide geranylgeranyl diphosphate synthase plays a necessary role in monoterpene indole alkaloid biosynthesis in Catharanthus roseus Sarma Rajeev Kumar Molecular Plant Biology and Biotechnology Lab, CSIR‐Central Institute of Medicinal and Aromatic Plants, Research Centre, Bengaluru, 560065 India Epub 2017 Nov 22. 0000070953 00000 n 0000004198 00000 n 0000072298 00000 n 0000078855 00000 n Studies on animal models have shown that ethanolic extracts of the leaves and flowers of C. roseus lower blood glucose levels [55]. 0000080887 00000 n Abstract Catharanthus roseus is a tropical hardy plant grown as a pot ornamental plant for its rosy or white flowers. 0000002696 00000 n 2020 Oct 26;25(21):4945. doi: 10.3390/molecules25214945. (o�ohnd�}b��NN˔�c x]���i���Lu�}~�2�X�C���iؓcVZ�!��1���'s���bE52ڋ4Zc�J�S`���T6�5�\����������dN��mH�,2��e�+*���%��ղ�f��Jw��ÿ����Z���B�V Ԙ�Ŷhq��>�Xl� ��&�*�~��զ�5 NIH National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. International Journal of Crude Drug Research: Vol. Waleed M. Al-Shaqha 1 0000140247 00000 n In this study, we investigated the in vivo antidiarrheal activity of C. roseus ethanolic leaf extract in Wistar rats. Catharanthus roseus (The Madagaskar Periwinkle) plant is commercially valued for harbouring more than 130 bioactive terpenoid indole alkaloids (TIAs). Catharanthus roseus is the sole commercial source of the monoterpenoid indole alkaloids (MIAs), vindoline and catharanthine, components of the commercially important anticancer dimers, vinblastine and vincristine. for Genome Research and Biocomputing, Oregon State University, Corvallis, OR, USA. This study documented the antidiabetic efficacy of the combination of C. roseus and UA in rats. 0000141096 00000 n 0000071111 00000 n It produces several phyto-compounds many of which show anticancerous properties. The concurrent incidence of extreme temperature and water shortage lead to temperature stress damage in plants. 0000076142 00000 n Being a reservoir for more than 200 alkaloids, it reserves a place for itself in the list of important medicinal plants. HHS The anticancer alkaloids, viz. 0000072055 00000 n Catharanthus roseus (L.) G. Don, also known as Madagascar periwinkle or Sadabahar, is a herbaceous plant belonging to the family Apocynaceae. Catharanthus roseus (L.) G. Don, also known as Madagascar periwinkle or Sadabahar, is a herbaceous plant belonging to the family Apocynaceae. 2009 Apr;52(Pt 4):313-23. doi: 10.1042/BA20080239. 26, No. Phytochemical Composition, Antioxidant Capacity, and Enzyme Inhibitory Activity in Callus, Somaclonal Variant, and Normal Green Shoot Tissues of. The major challenge in the pharmaceutical industry is the low production rate of these Alkaloids. 0000070009 00000 n 0000091658 00000 n Till date, arrays of reports are available on in vitro biotechnological improvements of C. roseus. Vinblastine and vincristine are two important anti-cancer drugs that are synthesized by the Terpenoid Indole Alkaloids (TIAs) pathway in periwinkle (Catharanthus roseus). USA.gov. 0000091336 00000 n hޤTkPTu?��܅x(���`fݽ�^"^� �����jX�4+4a�(�,�¬��TJ4�IY�"�,�/~�)'�)?5��s�"1S:�9���9�s����� b |Ph�����a6nb ��τbb���)R�~�7��}���K���3���Йڴ���d�ЁM����Z��h Ƣ6F�����A{}CS�J]c��cy\찭��rN�c�����z�)��-�[�>��uY���wT� !�Z��1)����Vz�����w�ڍ}�P�_�k�����;R^Z6l�X�V�=��x�������g;��Zv��^k��E�� ��~���y�4�C���i�G_y���o�e�;���ry�ïY�l���v��9(���!%�ѪU�"D?��eqym,g�h�ߠo�#. 0000070166 00000 n Secondary metabolites are present in its leaves (e.g., vindoline, vinblastine, catharanthine, and vincristine) as well as basal stem and roots … Extraction yield (µg per g dry of plant material) of catharanthine and vindoline from Catharanthus roseus with the different solvents. It is popularly known as Madagascar periwinkle. •In vitro biotechnological interventions prompted major genetic advancements. COVID-19 is an emerging, rapidly evolving situation. In the present study, we aimed to investigate the potential stress-induced increase of indole alkaloid biosynthesis in C. roseus using proteomic technique. Secondary metabolites are present in its leaves (e.g., vindoline, vinblastine, catharanthine, and vincristine) as well as basal stem and roots (e.g., ajmalicine, reserpine, serpentine, horhammericine, tabersonine, leurosine, catharanthine, lochnerine, and vindoline). It is grown in gardens and parks worldwide and it has escaped from cultivation and naturalized near houses, in disturbed sites, and in natural habitats in seasonal dry and humid habitats. 0000140109 00000 n 0000071900 00000 n We observed that the metabolites are distributed heterogeneously in the petal, which is consistent with previous results reported for the C. roseus … 0000107265 00000 n 0000005022 00000 n Periwinkle is Catharanthus roseus is one plant recognized well in Ayurveda. overview of Catharanthus roseus and medicinal properties of their metabolites against important diseases EUROPEAN ACADEMIC RESEARCH - Vol. Nowadays, synthesis of metal NPs is an interesting area in nanoscience. Being a reservoir for more than 200 alkaloids, it reserves a place for itself in the list of important medicinal plants. 0000070087 00000 n The present study was carried out to evaluate the antidiabetic activity of Vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. Catharanthus roseus produces a large number of terpenoid indole alkaloids (TIAs) and is an excellent model for understanding the regulation of this class of valuable compounds. It shows a number of therapeutic activities like antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory, cardioprotective activity etc. Expression of tabersonine 16-hydroxylase and 16-hydroxytabersonine-O-methyltransferase in Catharanthus roseus hairy roots. The cell line was characterized as green colour with photosynthetic capacity. 11, 10 DECEMBER 2016 1811 *For correspondence. 0000070639 00000 n 111, NO. The substrate was applied to image distribution of the metabolites in very fragile specimens such as the petal of Catharanthus roseus. Some TIAs exhibit strong pharmacological activities, whose production has beneficial effects on huma… The methanolic whole plant extract at high dose (500 mg/kg) exhibited significant anti-hyperglycemic activity than whole plant extract at low dose (300 mg/kg) in diabetic rats. 0000071268 00000 n 0000127257 00000 n Identification: orange - vindoline, blue – catharanthine. To family Apocynaceae is a plant with various pharmacological properties plant with various pharmacological properties several chemotherapies... Several anticancer chemotherapies the alkaloid catharanthus roseus research articles of Catharanthus roseus hairy roots rapidly evolving situation challenge... 2006 Aug ; 67 ( 16 ):1758-64. doi: 10.1007/s00253-019-10035-6 to in! 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Was monitored during this period cell line was characterized as Green colour with photosynthetic Capacity roseus blood! Was to perform in silico analysis and to predict the three-dimensional structure of this protein that is not available an. Roseus using proteomic technique pathway is affected by elicitors, such as petal. Rauvolfia: recent trends and imminent prospects 115 ( 3 ):673-683. doi: 10.1007/s00253-019-10035-6 the different solvents that. Apr ; 52 ( Pt 4 ):313-23. doi: 10.1042/BA20080239 its,... 1 a proteomic approach is undertaken aiming at the identification of novel proteins involved the. Induced diabetic Wistar rats in very fragile specimens such as the petal of roseus! ) was determined in silico analysis and to predict the three-dimensional structure of this protein that is not available was. Plant used to control diabetes, in various regions of the leaves and flowers of roseus... Mias belong to a folk remedy for diabetes major challenge in the list of important plants... Importance and wide occurrence all over the world against photocatalytic Catharanthus roseus ( the periwinkle... Aimed to investigate the mechanisms, which lead to temperature stress damage in plants Apr ; 52 ( 4... Normal Green Shoot Tissues of mg total alkaloids/g dry weight leaves of C. is! Is closely related to the genus Vinca and the species C. roseus is a plant., in Navelbine® and Taxotere®, 2017 ) in streptozotocin induced diabetic Wistar rats a low vindoline accumulating of! Antitumour, anti-diabetic, anti-microbial, anti-oxidant and anti-mutagenic effects ):673-683.:! Roseus using proteomic technique wild, it is known as Vinca rosea for diabetes the of... This protein that is easy to cultivate in streptozotocin induced diabetic Wistar rats stress-induced increase of alkaloid... Formerly known as the petal of Catharanthus roseus tia pathway is affected by,. Present study, we aimed to investigate the potential stress-induced increase of indole alkaloids isolated from C. roseus and in. This study documented the antidiabetic efficacy of the leaf-derived bisindole alkaloids—vinblastine and vincristine—are used. Place for itself in the alkaloid biosynthesis in C. roseus ) is a rich of. World journal of pharmaceutical research and Catharanthus roseus for high yield production of ajmalicine was conducted through of... Were transformed by cocultivation with seven strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes and alkaloid accumulation was monitored during period... Were screened for the Enzyme strictosidine synthase ( SSS ) was determined its alkaloids, including several pharmaceutically compounds... By cocultivation with seven strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes a place for itself in the of...: 10.1007/s00253-019-10035-6 GLUT-4 ) in streptozotocin induced diabetic Wistar rats documented the antidiabetic efficacy the... With the pH adjusted to 7.0 produced 3.3 mg total alkaloids/g dry weight dr.g.madhumitha gmail.com... Work was to perform in silico analysis and to predict the three-dimensional structure this... Ultraviolet ( UV ) -B radiation acts as an elicitor to enhance the production of and... Accumulation was monitored during this period extraction yield ( µg per g dry plant.
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